New research reveals that people who come off blockbuster slimming jabs like semaglutide or tirzepatide may regain lost weight at a significantly accelerated pace than those who stop conventional diet and exercise programs.
Published data in a prominent medical journal points out that while overweight individuals can lose substantial amounts of their body weight while using the jabs, the mass returns at an estimated rate of nearly a kilo each month after stopping.
"Users purchasing these treatments need to be informed of the potential of fast rebound weight gain when the medication ends," cautioned researcher Dr. Susan Jebb.
Such speed of recovery implies a reversion to starting mass within about one and a half years.
Weighing Therapies
The study, which examined dozens of trials involving thousands of participants, compared the effects of the injectable medications with conventional dieting.
The team emphasize that people who lose weight through diet and exercise generally see a more gradual weight regain—perhaps 0.1 kg a month—after stopping.
Understanding the Fast Rebound
Experts believe the mode of action of the jabs is key to understanding the amplified rebound.
The injections imitate a natural hormone called GLP-1, which moderates hunger.
"Long-term administration of the hormone concentrations far above than the body's typical production might result in the body to produce less of its own natural hormone, and may also lessen responsiveness to its effects," said Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication means hunger is unsuppressed, making excessive eating far more likely."
A Chronic Issue?
The NHS suggest the jabs for individuals with obesity-related health risks, alongside prescribed lifestyle changes.
Many experts say that, considering the high risk of relapse, the therapy is often ongoing.
This opinion is reinforced by drug manufacturers, who say that the results "underscore the chronic nature of excess weight," comparing it to managing conditions like diabetes.
Patient Experiences
Individuals who have stopped the jabs explain a powerful return of cravings.
"It felt as if a switch flipping and you're instantly starving," said one woman.
This difficulty is exacerbated if patients have not adopted permanent dietary or behavioural changes during treatment.
Widespread Adoption
Survey data show that millions of adults in the UK have used these injections in the last 12 months, with desire being substantial.
- Use is more common among females than males.
- The middle-aged demographic shows the greatest usage rates.
- Many access the drugs through private prescriptions rather than the NHS.
In conclusion, researchers emphasize that while the jabs are powerful agents for weight loss, they are not a standalone solution and maintained weight loss relies on ongoing behavioural support.
